Pregnancy is a special period in the process of women’s life. In this long process, fever and pain will inevitably occur.Application of non -steroidal anti -inflammatory drugs such as ibprofen and Losorofen (a commonly used heat -relieving analgesic drug) can affect the symptoms of discomfort, but will the application of pregnancy have adverse effects on the fetus?
Non -steroidal anti -inflammatory drugs are mainly effective by inhibiting the synthesis of prostaglandins.Animal experiments have shown that prostinone plays an important role in the permeability of endometrium vascular permeability, cysts bed and moltenization.The use of prostaglandin synthesis inhibitors, such as non -steroidal anti -inflammatory drugs, has proven to affect the implantation of fertilized eggs into bed.Data from epidemiological research show that after the use of prostaglandin synthesis inhibitors in early pregnancy, the risk of abortion, heart malformation and stomach cracks increases.Data from epidemiological research show that after the use of prostaglandin synthesis inhibitors in early pregnancy, the risk of abortion, heart malformation and stomach cracks increases.The absolute risk of cardiovascular malformations has increased from less than 1%to about 1.5%, which increases with the increase in the treatment dosage and duration.
As of 2017, the FDA has received 35 reports, reporting that the mothers who take non -steroidal anti -inflammatory drugs during pregnancy are low or kidney problems.5 The death of the newborn, 2 cases of renal failure and diagnosis of amniotic fluid were too low, and 3 cases of renal failure but did not be diagnosed with low amniotic fluid.There were 11 reports that the amniotic fluid level was low during pregnancy, and the amniotic fluid capacity was returned to normal after discontinuation of non -steroidal anti -inflammatory drugs.
The US FDA requires adding a new warning to the non -sterite anti -inflammatory drug manual, describing the risk of fetal kidney problems that may cause lack of amniotic fluid.FDA recommends that pregnant women who are pregnant at 20 weeks or later avoid using non -steroidal anti -inflammatory drugs.
(1) Twenty weeks of pregnancy
The use of non-steroidal anti-inflammatory drugs before 20 weeks of pregnancy should be based on benefits-risk assessment; some authoritative persons recommend avoiding taking non-steroidal anti-inflammatory drugs as much as possible during pregnancy.
(2) pregnancy exceeds 20 weeks
Non -steroidal anti -inflammatory drugs should be avoided in 20 weeks and after pregnancy, and taboos in the last three months of pregnancy should be avoided.
If non-steroidal anti-inflammatory drugs must be used during the 20-30 weeks of pregnancy, the minimum effective dose should be used in the minimum effective dose; if the use time for non-steroidal anti-inflammatory drugs is more than 48 hours, the right should be considered right.Monitoring of amniotic fluid; if there is too little amniotic fluid, non -steroidal anti -inflammatory drugs are discontinued and appropriately treated.
(3) During childbirth
It is not recommended to administration during childbirth. If the start time of the application of delivery may be delayed, the duration of the duration increases, and the bleeding tendency of maternal and baby bleeding is greater.
(4) Women who have difficulty in pregnancy or are undergoing infertility examinations
Non -steroidal anti -inflammatory drugs may damage women’s fertility; women who are pregnant or are undergoing infertility examinations should consider discontinuous treatment of non -sterite anti -inflammatory drugs.
